Metabolomics is a comprehensive qualitative and quantitative analysis of low-molecular-weight metabolites in living organisms. Measurements are mainly made using a mass spectrometer. Because metabolites have a direct effect on phenotype compared to genes and proteins, research has become popular in recent years, and metabolomic research is expected in fields such as disease diagnosis.
GL Sciences supplies important pre-processing and analysis tools for the pharmaceutical R&D and omics research. We also support the sample pre-treatment and chromatographic analysis of the trace amounts in forensic research and clinical studies.
Proteomics
Proteomics-related research has developed rapidly recently, it has been used for a variety of purposes, including protein identification, biomarker search, and quantification, requiring accurate and reproducible results. We offer products ranging from preprocessing to analysis that are tailored to proteomics workflows.
Metabolomics
Quasi-drugs and Designated Quasi-drugs
Forensic Science
Clinical Research
- Pharmaceuticals Analysis : Pharmaceuticals analysis is performed in a variety of biological samples. Examples include clinical trials in drug development and therapeutic drug level management (TDM).
Solid-phase extraction has been commonly used as a sample pretreatment, but in recent years, improved sensitivity of analytical instruments has led to the use of solid-phase extraction and deproteinization of trace samples. - Clinical Proteomics : Progress in functional analysis of proteins has led to the identification of proteins that cause disease.Research is underway to use the protein as a disease marker for diagnostic.
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Clinical Metabolomics :Like clinical proteomics, endogenous low-molecular-weight compounds (metabolites) in living organisms have been used as disease markers. In such studies, a variety of techniques (GC/MS, LC/MS, CE/MS, SFC/MS) have been used because of the diversity of molecules involved.
Pharmaceutical R&D
Antibody Purification
Antibodies have been used in a variety of studies, including immunological analysis, functional analysis of proteins, and screening analysis. In recent years, antibody drugs have been actively developed to treat cancer.
We propose antibody purification columns and automation systems.
Antibody-Purified Column, MonoSpin ProA, MonoSpin ProG
- Rapid purification by centrifugation
- Prepare spin columns for trace samples, large-volume L-type, 96 plates for multiple samples
- Also available for light sample concentration.
- Antibody columns can also be prepared.
Protein Purification
Molecules affect biological functions, such as biomarkers that elucidate biological mechanisms, and allergens cause allergies most of them are proteins. To analyze the function and structure of these proteins, we need to isolate them. It is possible to isolate those proteins using LC columns and solid-phase columns as shown below.
Synthesis Study
Formulation Research
In addition, membrane permeability studies such as PAMPA and Caco-2 have been conducted for DDS (Drug Delivery System).GL Sciences also offers an automation system centered on an automatic dispenser.
Pharmacokinetic Research
The most important parameter for what a drug moves in the body is the blood level, and all drugs are described as Absorption, Distribution, Metabolism, and Excretion and are described in four acronyms as ADME.
Energy Science provides a wide variety of HPLC columns that are critical for analyzing ADME processes.
- Recommended column InertSustainSwift C18 with low adsorption and rapid equilibration
- Recommended column InertSustain AQ-C18 for reversed phase modes to enhance highly polar retention
- Second-choice column InertSustain Penylhexyl when AQ-C18 cannot separate